Role of ERalpha-ERRalpha Heterodimers in Tamoxifen-Resistant Breast Cancers
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چکیده
s and Presentations: Mertz, J. E., Esch, A. M., and Burgess, R. R.. Estrogen-related Receptor Alpha Target Genes: Identification of Novel Biomarkers of Aggressive Breast Cancer. DOD-BCRP Era of Hope Conference, Orlando, FL, August, 2011. Mertz, J. E. Kraus, R. J., and Lillios, N. P. Regulation of Estrogen-related Receptor Alpha Activity by its Tyrosine at Residue 400. DOD-BCRP Era of Hope Conference, Orlando, FL, August, 2011. Mertz, J. E., Kraus, R. J., Golden, S. K., and Esch, A. M. Estrogen-related Receptor Alpha and Estrogen Receptor alpha form Heterodimers in a Ligand-dependent Manner. DOD-BCRP Era of Hope Conference, Orlando, FL, August, 2011.
منابع مشابه
Prognosis of hormone-dependent breast cancers: implications of the presence of dysfunctional transcriptional networks activated by insulin via the immune transcription factor T-bet.
Estrogen receptor alpha (ERalpha)-positive breast cancers that co-express transcription factors GATA-3 and FOXA1 have a favorable prognosis. These transcription factors form an autoregulatory hormonal network that influences estrogen responsiveness and sensitivity to hormonal therapy. Disruption of this network may be a mechanism whereby ERalpha-positive breast cancers become resistant to thera...
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Oestrogen receptor-alpha (ERalpha) is an important prognostic marker in breast cancer and endocrine therapies are designed to inhibit or prevent ERalpha activity. In vitro studies have indicated that phosphorylation of ERalpha, in particular on serine 118 (S118), can result in activation in a ligand-independent manner, thereby potentially contributing to resistance to endocrine agents, such as ...
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تاریخ انتشار 2012